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Bounce Chix |best| Access

Bounce Chix identified a clear opportunity: create a girl-centric space that feels like a clubhouse with springs. It’s a place where tweens can be physically active without the pressure of co-ed competition, where they can celebrate birthdays without the chaos of a general admission crowd, and where fitness is disguised as pure fun.

The game's primary selling point—typical of the shareware era—was its "edgy" or "adult" humor. Upon completing a level or reaching a high score, the game would reward the player with a pixelated image of a woman in lingerie or swimwear. This was a common tactic in the shareware market to entice teenage boys to register (buy) the full version of the game.

Bounce Chix and Dragons Последние записи: [Overwatch] · Ruan Mei [Honkai Star Rail] · https://www.pixiv.net/en/artworks/136309570 Bounce Chix - Mike DeBalfo - Comic Art Fans

Krasnov V.S.

Pavlov First St. Petersburg State Medical University

Kolontareva Yu.M.

Novartis Pharma LLC

bounce chix

Siponimod: a new view at the therapy of secondary progressive multiple sclerosis

Authors:

Krasnov V.S., Kolontareva Yu.M.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2021;121(7): 124‑129

DOI: 10.17116/jnevro2021121071124

Read: 10020 times

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Table of contents
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SIPONIMOD: A NEW VIEW AT THE THERAPY OF SECONDARY PROGRESSIVE MULTIPLE SCLEROSIS
SIPONIMOD: A NEW VIEW AT THE THERAPY OF SECONDARY PROGRESSIVE MULTIPLE SCLEROSIS

To cite this article:

Krasnov VS, Kolontareva YuM. Siponimod: a new view at the therapy of secondary progressive multiple sclerosis. S.S. Korsakov Journal of Neurology and Psychiatry. 2021;121(7):124‑129. (In Russ.)
https://doi.org/10.17116/jnevro2021121071124

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
МСФ на ЯМ
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Abstract:

Siponimod is a selective modulator of sphingosine-1-phosphate (S1P) receptors of types 1 and 5, registered in the Russian Federation for the treatment of patients with secondary progressive multiple sclerosis (SPMS), regardless of the presence or absence of exacerbations. The effectiveness of the drug in comparison with placebo was demonstrated in patients with SPMS in the international clinical trial EXPAND (phase III). This review devotes actual problems in the treatment of patients with SPMS, discusses the pathophysiology of multiple sclerosis progression, describes the peripheral and central mechanisms of siponimod action and its differences from fingolimod. According to analysis of scientific literature experimental, clinical and neuroimaging data are presented, which could explain the reasons for the successful use of siponimod in patients with SPMS, taking into account the pathophysiological mechanisms of the development of progression and the mechanisms of drug action.

Keywords:

secondary progressive multiple sclerosis
siponimod
neurodegeneration
remyelination

Authors:

Krasnov V.S.

Pavlov First St. Petersburg State Medical University

Kolontareva Yu.M.

Novartis Pharma LLC

Received:

20.04.2021

Accepted:

04.06.2021

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bounce chix
bounce chix

Bounce Chix identified a clear opportunity: create a girl-centric space that feels like a clubhouse with springs. It’s a place where tweens can be physically active without the pressure of co-ed competition, where they can celebrate birthdays without the chaos of a general admission crowd, and where fitness is disguised as pure fun.

The game's primary selling point—typical of the shareware era—was its "edgy" or "adult" humor. Upon completing a level or reaching a high score, the game would reward the player with a pixelated image of a woman in lingerie or swimwear. This was a common tactic in the shareware market to entice teenage boys to register (buy) the full version of the game.

Bounce Chix and Dragons Последние записи: [Overwatch] · Ruan Mei [Honkai Star Rail] · https://www.pixiv.net/en/artworks/136309570 Bounce Chix - Mike DeBalfo - Comic Art Fans

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