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| Feature | Standard Retrovirus | IMOG036 Yamanaka System | | :--- | :--- | :--- | | | Integrating retrovirus | Non-integrating Sendai virus or episomal | | Factor Ratio | Fixed by viral titer | Optimized 1:1:1:1 with rotatable c-Myc | | Reprogramming Efficiency | 0.01–0.1% | 1–5% (up to 10% in some cell lines) | | Risk of Insertional Mutagenesis | High | Negligible | | Residual Vector Clearance | Difficult | Easy (temperature-sensitive or drug-selected) | | Cost per Experiment | Low initial, high QC failure | Higher upfront, but 50x more successful colonies |