| Patent | Publication | Key Claims | |--------|-------------|------------| | US 11,925,487 (2024) | WO 2024/108765 | Core pyrido‑pyrimidine scaffold, fluorobenzyl substitution, morpholine linker; method of use for NLRP3 inhibition. | | US 12,101,023 (2025) | US 2025/041215 | Crystalline forms A–D of JUQ‑578; improved bioavailability formulations. | | US 12,189,842 (2025) | US 2025/067890 | Combination therapy with GLP‑1 agonists for T2D; synergistic reduction of IL‑1β. |
is a production code identifying a specific film within the Japanese adult video (JAV) industry, featuring actress Tsukasa Aoi . Released by the studio Madonna , which typically specializes in the "mature" or "stepmother" subgenres, this title follows the thematic conventions of the "Jukujo" (mature woman) category. Production and Context JUQ-578