You can typically fix this error by following these standard troubleshooting steps:
Do not install RE6 in any folder with spaces, symbols, or non-English characters. Use the Steam “Move install folder” function to a drive root.
Launching the game from an external USB drive has been known to cause file-read failures that are resolved by moving the game to an internal SSD. Recommended Fixes Verify Integrity of Game Files: Open your Steam Library and right-click Resident Evil 6 .