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SONE‑096 represents a rare “full” DHPS inhibitor with exceptional potency, a favorable safety profile, and a synthetically tractable scaffold. Ongoing SAR work and formulation optimization aim to overcome its moderate oral bioavailability, positioning it as a strong candidate for treating resistant bacterial infections. sone096 full
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2. **Oxidation** 4‑methoxy‑acetophenone → 4‑methoxy‑benzoic acid (KMnO₄, reflux).
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